3,5-Di-tert-butylsalicylaldehyde, also known as 3,5-Di-tert-butyl-2-hydroxybenzaldehyde, is an organic intermediate, which can be prepared from 2, 4-di-tert-butylphenol through one-step reaction. It has been reported that it can be used to prepare dimethyl ethylenediamine tert-butylphenol and (S,S)-salenCo (II) catalyst.
3,5-Di-tert-butylsalicylaldehyde is used in the synthesis of Mn(III)-salen complex and its diamino precursor 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-3-O-methyl-β-L-idofuranose, chiral Schiff base ligand for an enantioselective copper-catalyzed addition of phenyl acetylene to imines, chiral oxazolidine ligand for the enantioselective addition of diethyl zinc to aldehydes and tin Schiff base complexes with histidine analogues.
3,5-Di-tert-butylsalicylaldehyde is a salicylaldehyde derivative with antibacterial activity used in the preparation nickel complexes. 3,5-Di-tert-butylsalicylaldehyde is structurally related to 3,5-di-t-butylcatechol (DTCAT) but is not as potent an activator of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).
1. Steric Hindrance: 3,5-Di-tert-butylsalicylaldehyde contains two bulky tert-butyl groups attached to the phenolic ring. This steric hindrance restricts molecular interactions, making it challenging for other molecules or metal ions to access specific reactive sites.
2. Antibacterial Activity: The compound exhibits antibacterial properties, which can be beneficial in various applications, such as antimicrobial coatings or additives in certain products.
3. Coordination Chemistry: 3,5-Di-tert-butylsalicylaldehyde can serve as a ligand in coordination complexes with various metal ions. Its steric hindrance influences the geometry and stability of the resulting metal complexes.
4. Chirality: Due to its steric configuration, 3,5-Di-tert-butylsalicylaldehyde can serve as a chiral building block for the synthesis of chiral catalysts and ligands. This property is significant in asymmetric catalysis and organic synthesis.
5. Electronic and Photophysical Properties: The tert-butyl groups' presence can influence the electronic and photophysical properties of 3,5-Di-tert-butylsalicylaldehyde and its derived compounds, making them interesting for optoelectronic and materials research.
6. Applications in Chemical Research: 3,5-Di-tert-butylsalicylaldehyde is widely used in chemical research and the development of new materials, particularly in the synthesis of complex organic molecules.
7. Precursor in Nickel Complexes: The compound is often employed in the preparation of nickel complexes, which can have diverse applications in catalysis and materials science.
8. Structural Similarity: While structurally related to 3,5-di-t-butylcatechol (DTCAT), 3,5-Di-tert-butylsalicylaldehyde does not possess the same potent activating properties of rat skeletal muscle ryanodine receptor Ca2+ channel (RyRC).
1. Coordination Chemistry
3,5-Di-tert-butylsalicylaldehyde can act as a ligand in coordination complexes with different metal ions. These metal complexes find use as catalysts in organic transformations and materials synthesis.
2. Chiral Building Block
Its chiral nature makes 3,5-Di-tert-butylsalicylaldehyde a valuable building block for the synthesis of chiral catalysts and ligands. These compounds play a crucial role in asymmetric catalysis, which is essential for the production of enantiomerically pure compounds.
3. Antibacterial Agents
3,5-Di-tert-butylsalicylaldehyde's antibacterial activity makes it useful in formulating antimicrobial coatings, additives, or treatments for various applications, including medical devices, paints, and coatings.
4. Organic Synthesis
The compound is utilized in chemical research and organic synthesis as a precursor for the preparation of complex organic molecules and pharmaceutical intermediates.
5. Nickel Complexes
3,5-Di-tert-butylsalicylaldehyde is employed in the synthesis of nickel complexes, which have applications in catalysis and materials science.
6. Materials Science
Its unique electronic and photophysical properties make it interesting for research in the development of optoelectronic materials and related devices.
7. Ligands in Metal Coordination
As a ligand, 3,5-Di-tert-butylsalicylaldehyde influences the coordination geometry and stability of metal complexes, making it important in the design and synthesis of novel materials.
| Product Name |
3,5-Di-tert-butylsalicylaldehyde |
| Cas No. |
37942-07-7 |
| Molecular Formula |
C15H22O2 |
| Molecular Weight |
234.33 |
| Appearance |
White to yellow powder |
| Density |
1.006 |
| Purity |
99% Min |
| Solubility |
Soluble in DMSO and methanol. |
| Boiling point |
277.6 °C at 760 mmHg |
| Melting point |
58-60ºC |
| Flash point |
116.1 °C |
| Refractive index |
1.527 |
Storage: Keep in dark place,Sealed in dry,Room Temperature.
Package: 50kg/bag or as per your particular request.
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